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Study highlights risks of cesarean births to future pregnancies

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Women who have cesarean births at an advanced stage of labor are about eight times more likely to develop scars in the womb which are known to increase the likelihood of premature births in future pregnancies, UCL researchers have found.

The study, published in the American Journal of Obstetrics & Gynecology, looked at how the stage of labor when the operation is performed affects where the scar forms and how well it heals. More than 40% of all births in high-income countries, including England, are now by cesarean.

As labor progresses, the baby moves further down the woman’s womb towards the vagina. In preparation for giving birth, the woman’s cervix—the opening of the womb—opens (dilates) up to 10 centimeters. In some cases, doctors may need to intervene and perform a cesarean procedure for safety reasons. It is a major operation and leaves a scar in the womb.

An earlier study by the same team of UCL researchers found that when this internal scar was close to the cervix, the risk of the woman having a preterm birth (before 37 weeks) in future pregnancies was significantly increased.

In their new study, they wanted to better understand the factors that influence where in the womb these scars are located by scanning women after a cesarean birth.

They found that women who had a cesarean at an advanced stage of labor—when the cervix was almost fully (around 8 cm) or completely open—were about eight times more likely to have scars that formed within or near the cervix. In addition, a low position of the baby in the womb increased the chance of a low scar.

The researchers also found that scars lower down the womb healed less well than those higher up the womb.

They say their findings will help better plan follow-up care for women in future and ways for them to avoid preterm births with future pregnancies. The results should also allow doctors to explore ways to improve surgical techniques to reduce risks in the future, they add.

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They are calling for more research into the impact of cesarean scars on gynecologic symptoms and future pregnancies and to help develop techniques to improve cesarean-scar healing.

Lead author Dr. Maria Ivan (UCL EGA Institute for Women’s Health) said, “We knew that having a cesarean birth can damage the cervix. Our study is the first to look at where that damage in the womb is depending on how advanced the labor is when the operation takes place. Our findings have significant implications for women who have a cesarean late in their labor and want to have more children. This is particularly relevant given the huge increase in the number of women who are having cesarean births over the last decade.

“These fresh insights can help shape the future care for women having advanced labor cesarean births, helping doctors better prepare women for giving birth and hopefully also leading to improved surgical techniques which reduce the risk of future complications that cesarean delivery scars can cause.”

Ninety-three women who had a cesarean delivery during active labor (defined as the cervix being at least four centimeters dilated) took part in the study. The researchers examined them using transvaginal ultrasound between four and 12 months after birth to see if the cesarean operation had left a scar, and if so, where it was in the womb.

Almost all of the 93 women—90—were found to have a visible internal scar. The researchers found that for each one-centimeter increase in cervical dilatation during labor, the scar was positioned 0.88mm lower down the womb and closer to the cervix.

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Fifty-two of the women’s scars (57.8%) were in the higher part of the womb, with the scars in the rest of the women located either close to the cervix (19 women or 21.1%) or within it (also 19 women or 21.1%).

From this, the researchers worked out that having an advanced labor cesarean birth was associated with an eightfold higher risk of the scar being located near or within the cervix compared to cesarean births at an earlier stage of labor.

The researchers also looked at the impact the position of the scar had on how well it healed.

Indicators of impaired scar healing include the presence of a scar “niche”—a gap or defect in the wall of the womb at least two millimeters deep. These niches form a pouch where blood can accumulate and may be associated with infertility, irregular menstrual bleeding or complications in future pregnancies.

Based on these indicators, they found that scars which formed close to or within the cervix did not heal as well as scars higher up the womb, posing a greater risk of complications in future pregnancies.

Co-author Professor Anna David, EGA Institute for Women’s Health, National Institute for Health Research, University College London Hospitals Biomedical Research Centre, and Deputy Director of charity Tommy’s National Centre for Preterm Birth Research, said, “Cesarean birth in advanced labor is known to be linked with preterm birth. Our findings highlight the importance of healing of the cesarean scar in the womb and that the stage of labor and low position of the baby can impact how this happens.”

Dr. Jyotsna Vohra, Director of Research, Programmes and Impact at Tommy’s, the pregnancy and baby charity, said, “Unplanned cesarean births can be very stressful, especially when carried out in an emergency to make sure the baby arrives safely. Women who have experienced this may already be feeling anxious going into their next pregnancy, and to be then told they’re at increased risk of giving birth early will only add to the anxiety.

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“This new research paves the way for better prediction and prevention of preterm birth following a previous cesarean birth. We’re working closely with health care professionals to make sure this research breakthrough translates to improvements in care for women and birthing people whose babies are most at risk of being born too soon.”

The number of women having cesarean births has risen sharply in England in recent years to 42% (225,762, of which 99,783 were elective and 125,979 registered as emergency cesareans) of all deliveries in 2023–24 compared with 26% (166,081 deliveries) in 2013–14.

More information:
Maria Ivan et al, Postnatal healing of cesarean scar: an ultrasound study, American Journal of Obstetrics and Gynecology (2025). DOI: 10.1016/j.ajog.2025.09.013

Provided by
University College London


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Study highlights risks of cesarean births to future pregnancies (2025, October 7)
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